The United Nations has warned that 400,000 people are "trapped" in the central Mosul area under siege-like conditions as Iraqi forces battle the Islamic State group for the city's west.
"Federal Police and Rapid Response Division units began to advance today on the southwestern axis of the Old City," Lieutenant General Raed Shakir Jawdat, the commander of the federal police, said in a statement.
Jawdat said that one of their targets is Faruq Street, which runs near the Al-Nuri mosque.
IS chief Abu Bakr al-Baghdadi made his only known public appearance at the mosque after IS seized Mosul in 2014, calling on Muslims to obey him.
IS overran large areas north and west of Baghdad in 2014, but Iraqi forces have since retaken much of the territory they lost.
Iraqi forces launched the operation to retake Mosul, the country's second city, in October, retaking its eastern side before setting their sights on its smaller but more densely-populated west.