The incident occurred on the Jabalpur-Mandla road.
"While six people died, two others sustained serious injuries and are undergoing treatment. Rescue operation is underway," Deputy Inspector General of Police, Jabalpur, B S Chouhan, told PTI.
Following the incident, a mob blocked the road and pelted stones at a police team and also torched their vehicle, he said.
According to Chouhan, the 16-wheel truck was coming from Chhattisgarh and it has caused heavy damaged.