The Local Coordination Committees activist collective and the Britain-based Syrian Observatory for Human Rights both reported the fighting for the airfield, which is just outside of the city of Deir el-Zour.
Almost all of the surrounding province is under IS control.
The Observatory said today that at least 19 government troops have been killed in the fighting, which began overnight with a suicide bombing on a Syrian military position near the air base. It said seven IS fighters have been killed.