The suspect detonated explosives when police raided an apartment building in the town of Gaziantep suspected of being a jihadist hideout, the governor's office said in a statement.
The raid was conducted as part of the investigation into a double suicide bombing on October 10 in Ankara that killed 102 activists gathering for a peace rally, Turkish media said.
The attack came as leaders gathered in the Mediterranean resort city of Antalya, 500 kilometres to the west, for a G20 summit where the fight against terrorism was a major discussion point, following this weekend's Paris attacks.
Also yesterday, the police arrested seven suspected IS members in Ankara, state-run Anatolia news agency reported.
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The same day, IS claimed responsibility for the gun and suicide attacks that killed 129 people across Paris late Friday.
A suicide vest, assault rifles, ammunition and other explosive devices were found in the raid at Gaziantep, the official statement said.
Turkey has been on the hunt for IS extremists after a series of deadly attacks including bombings on October 10 in Ankara which killed 107 people.