IS said a "security detachment" had targeted a "tourist bus carrying Jews" and that there were "killed and wounded in the ranks of the Jews and hotel security forces".
But officials and witnesses said yesterday that a gang of youths hurled fireworks and fired birdshot at a bus and police guarding the hotel without hurting anyone.
There was no reference to Jews, but to Arab Israelis, who were staying at the Three Pyramids Hotel.
The interior ministry said unknown assailants had gathered outside the hotel and targeted police guarding it, who fired back.
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It added that one of the attackers was arrested.
Hotel employee Yasser Fakhreddin said the group "threw fireworks and fired birdshot at the glass facade of the hotel as well as the windows of an empty bus waiting to pick up the Arab Israeli tourists".
An AFP photographer said bits of the facade and the bus's windows had been broken.
The IS statement, published online, claimed the attack was in response to IS leader Abu Bakr al-Baghdadi's call "to target the Jews everywhere".
Egypt, which has fought several wars with Israel, is one of only two Arab nations, along with Jordan, to have signed a peace treaty with the Jewish state.
The country has been roiled by mainly jihadist violence since the army ousted Islamist president Mohamed Morsi in 2013.
The attacks have largely focused on security forces in reprisal for a fierce crackdown on Morsi supporters.