In a major foreign policy speech which was mainly focused on Iran and the rise of ISIS, Bush urged the US to disapprove the recently-inked Iranian nuclear deal, or else the next US President would have to undo the damage.
Bush, who is the brother and son of two former US presidents, also blamed Democratic presidential frontrunner Hillary Clinton for the rise of ISIS.
"Despite elaborate efforts by the administration to avoid even calling it by name, one of the very gravest threats we face today comes from radical Islamic terrorists.
"The terrorists are possessed by the same violent ideology that gave us 9/11, and they are on the offensive and gaining ground. It is not true, and was wishful thinking by the Administration to claim, that the tide of war is receding," he said.
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"What we are facing in ISIS and its ideology is, to borrow a phrase, the focus of evil in the modern world. And civilised nations everywhere, especially those with power, have a duty to oppose and defeat this enemy.
"No leader or policymaker involved will claim to have gotten everything right in the region, Iraq especially," he said.
Noting that the threat of global jihad, and of the Islamic State in particular, requires all the strength, unity, and confidence that only American leadership can provide, Bush said: "Radical Islam is a threat we are entirely capable of overcoming, and I will be unyielding in that cause should I be elected President of the United States."
Observing that Egypt and Saudi Arabia, the most populous Arab country and the wealthiest, are important partners of the United States, he alleged those relationships have been badly mishandled by this administration.
"Both countries are key to a better-coordinated regional effort against terrorism. We need to restore trust, and work more closely with them against common threats. We have very capable partners, likewise, in the United Arab Emirates, who are willing and able to take the fight to the extremists," he said.