"I think that we have to look at ISIS as the leading threat of an international terror network. It cannot be contained, it must be defeated," Clinton, the leading Democratic presidential candidate, said during a Democratic presidential debate yesterday.
Her remarks came a day after the horrific terror attacks in Paris that claimed over 120 lives. The responsibility of the attacks has been claimed by ISIS.
"We are not at war with Islam," Clinton, the former secretary of state, said, adding that, "We are at war with violent extremism."
Clinton stressed that this cannot be an American fight, although American leadership is essential.
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"We need to have a resolve that will bring the world together to root out the kind of radical jihadist ideology that motivates organisations like ISIS, a barbaric, ruthless, violent jihadist terrorist group," she said.
Clinton's rival Sanders said he wants to get this planet rid of ISIS.
"International terrorism is a major issue that we have got to address today," he said but disagreed with Clinton that the bulk of the responsibility is not America's.
"In fact, I would argue that the disastrous invasion of Iraq, something that I strongly opposed, has unravelled the region completely and led to the rise of al-Qaeda and to ISIS," Sanders said.