Built by US aerospace giant Lockheed Martin, the first two planes' arrival in Israel is being welcomed as a major event for the country's military as it seeks to maintain dominance in the turbulent Middle East.
US Defence Secretary Ashton Carter is to attend the arrival along with his Israeli counterpart Avigdor Lieberman at the Nevatim air base in the country's south.
The delivery of the first two of 50 F-35s to be purchased by Israel comes as the years-long development of the most expensive plane in history reaches a critical stage.
"I think we don't fully understand the big advantage of the F-35," an Israeli air force official said.
More From This Section
"I think it's going to be learned in the next few months, maybe years. I think it's a very super-tech airplane."
Israel has given it the name "Adir" -- which means "mighty" in Hebrew. Its first planes are expected to be operational within a year after delivery.
Among their main features are advanced stealth capabilities to help pilots evade sophisticated missile systems.
The single-pilot jets can carry an array of weapons and travel at a supersonic speed of Mach 1.6, or around 1,200 miles per hour (around 1,900 kilometres per hour).
It is unclear if Israel's planes will be able to deliver nuclear bombs. Israel is believed to be the Middle East's sole nuclear-armed power, though it has never acknowledged it.
The ultra-high-tech helmet, at a cost of some USD 400,000 each, sounds like something out of a science-fiction film.
Thermal and night vision as well as 360-degree views are possible with cameras mounted on the plane.
Israeli firm Elbit Systems has been involved in the helmet's production.
In Israel, the planes, designed for multiple combat situations, will initially replace a group of ageing F-16s.
They are seen as helping the country maintain its edge in the Middle East, particularly as its main enemy Iran seeks further influence in the region.
"The F-35 has been designed to deal with the most advanced threat systems now being fielded in the Middle East," Lockheed Martin's Steve Over told AFP by email.