The incident occurred at the Gush Etzion Junction, a busy intersection south of Jerusalem that has been the site of multiple attacks over the past year and a half.
Israel's national rescue service said the 60-year-old Israeli man suffered a head injury and was taken to a Jerusalem hospital.
No other details about the attacker were immediately available.
Since September 2015, Palestinians have killed 42 Israelis, 2 visiting Americans and a British tourist in a wave of stabbing, shooting and car-ramming attacks.
Israel says the violence is fueled by Palestinian incitement. Palestinians say it stems from anger over 50 years of occupation.
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