Avigdor Lieberman also accused the Palestinians of breaking the terms of the US-brokered peace talks, saying they should "pay a price" for this.
The remarks came as the Israeli-Palestinian peace talks have become embroiled in their worst crisis since US Secretary of State John Kerry persuaded the two sides last summer to resume talks for nine months.
Under the terms of renewed talks, Israel had promised to release 104 long-held Palestinian prisoners in four groups, while the Palestinians said they would suspend a campaign to sign up Palestine, recognised by the UN General Assembly as a non-member observer state in 2012, for as many as 63 UN agencies, treaties and conventions.
Lieberman said the final prisoner release was off the table unless the Palestinians reversed course on the UN bids.
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"We are in favour of negotiations but the previous offer about releasing prisoners doesn't exist anymore," Lieberman told Israel's Army Radio today. "Whoever broke the rules has to bear responsibility ... Therefore the previous offer is not relevant anymore."
Mohammed Ishtayeh, an aide to Abbas, said yesterday that the letters of accession will not be withdrawn and that the step is irreversible. He said the Palestinians were ready to widen their bid.
The crisis in talks has also spurred Kerry to say the US would rethink its mediator role.
Kerry originally hoped for a peace deal by April 29. But after months without progress in the Mideast negotiations, he lowered his sights, saying he sought a framework deal by that date. In recent weeks, negotiations focused on reaching agreement on extending the talks into 2015.