Pampanini, who had been hospitalised since October according to Corriere della Sera, starred in over 50 films during her 1950s heyday.
She came to prominence as a Miss Italy contestant in 1946 (her failure to win caused a tabloid outcry) and went on to work with a long list of famous film figures, including Buster Keaton, Marcello Mastroianni, Alberto Sordi, Toto and Jean Gabin.
With her voluptuous, wide-eyed looks, Nini Pampan, as she was nicknamed in France, became a symbol of Italian beauty around the world.
Pampanini never married but was reported to have sparked the romantic ardour of a string of famous men, from Cuban leader Fidel Castro and Egypt's King Farouk I to Orson Welles and Omar Sharif.
Described as both a devout Catholic and a lifelong diva, she worked only occasionally after giving up full-time acting to look after her elderly parents in the mid-1960s.