The upcoming movie, sequel to 2012 'Magic Mike', also stars Channing Tatum, Matt Bomer, Joe Manganiello and Kevin Nash among others.
Smith, 46, talked about the film on Ellen DeGeneres on her talk show, reported Us magazine.
"You know, it was really interesting, because there were a lot of guys. There were a lot of famous people...So, everywhere I go, there's someone who's been in their underwear with my wife," he joked to DeGeneres on her show, gesturing toward her DJ Stephen 'tWitch' Boss, who has a role in the film. "It's just awkward. It's just awkward, Ellen."