The 48-year-old actress has appeared nude in the men's magazine many times but her cover shoot in the upcoming January/February (16) issue will be her last as the publication's bosses move forward with plans to scrap their naked models.
And to accompany her stylish Ellen von Unwerth shoot, The Interview star Franco, a frequent Playboy contributor, agreed to play interviewer.
During their chat, Anderson reminisced about her first Playboy shoot in 1989 after she was spotted at a football game.
"The cameraman zoomed in on me and everyone screamed and yelled, so they brought me down to the 50-yard line.
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