The thriller from J J Abrams' Bad Robot Productions and Warner Bros TV will be a nine-hour miniseries, reported Ace showbiz.
In the upcoming project, Franco, 36, will play Jake Epping. He is a high-school English teacher who travels back in time to early September 1958 and tries to prevent President Kennedy from being shot.
Epping's mission, however, is threatened by Lee Harvey Oswald and the past which doesn't want to change.
The '11/22/63' project was announced last year.