The Oscar winner will appear on the December 8 episode, with musical guest Ne-yo.
It is for the second time that the actor is hosting the popular show. He had hosted it back in 2000.
Fox will next be seen on the big screen in Quentin Tarantino's 'Django Unchained', which hits theaters December 25.
The film stars Foxx as a slave-turned-bounty-hunter, who is searching for his wife. Leonardo DiCaprio plays the antagonist in the movie.