The 55-year-old actress, whose last regular TV role was in 1989 'Anything But Love', would be playing Caroline, the quadruplets' mother, who is a dynamic and distinguished physician, running the Easton Hospital, said The Hollywood Reporter.
The medical drama is based on the Israeli format, 'Ran Quartet', which revolved around three brothers and a sister, who grew up on a reality show.
The actress has guest starred in 'NCIS: Naval Criminal Investigative Service' and 'New Girl'.