The 44-year-old actor, who is also the frontman of rock band Thirty Seconds to Mars, said Bowie can be an inspiration for anything creative, reported Entertainment Weekly.
"I think David Bowie's probably an inspiration for, like, almost anything you could do creatively," Leto said.
The actor also hopes his Bowie-inspired Joker may get his own standalone movie.
"I think that would be great. To dive in deeper to the Joker and expand the story and to learn a bit more about this sick and twisted - but lovely - strange man," he said.