"I am going to participate in the Cauvery River Authority meeting. My focus and concentration are on the meeting," Jayalalithaa told reporters before leaving for Delhi.
The CRA, headed by Prime Minister Manmohan Singh, has been convened following the Centre's assurance to the Supreme Court recently.
Jayalalithaa had repeatedly urged the Centre to convene the CRA to discuss the water-sharing dispute with Karnataka.
She had yesterday held discussions with senior cabinet colleagues and officials to finalise the state's strategy to be adopted at the meeting.