Top seed Jayaram, who has clinched this title three times in his career, notched up a 21-15 21-18 win over Brazil's Ygor Coelho De Oliveira, seeded eighth, in a 32-minute match at the Topsportcentrum Almere here.
The 29-year-old Indian will next face fifth seeded Anders Antonsen of Denmark.
Indian combo of Pranaav Cherry Chopra and Sikki Reddy also reached the mixed doubles semifinals last night.