The film a fact-based tale about Barry Seal (Cruise), a pilot who was a gun runner and drug trafficker, who reportedly transported contraband for the CIA and the Medellin cartel during the 1980s.
The title refers to Mena, Arkansas in US, where a lot of the illegal activity took place, reported Deadline.
Mays, 35, will play Dana Sibota, the Assistant Attorney General of Arkansas.