DeFranco's family told The Associated Press that the famed musician died Wednesday evening at a Florida hospital.
DeFranco's wife, Joyce, said he had been in declining health in recent years.
DeFranco, a member of the American Jazz Hall of Fame, performed at venues around the world for 75 years and recorded with musicians including Sinatra, Holliday, Art Tatum, Ella Fitzgerald and Tony Bennett. He conducted the Glenn Miller Orchestra for eight years from 1966 to 1974.
DeFranco was recognized 16 times with the Playboy All-Star award for top jazz clarinetist in the world.
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"We have received condolences from around the world," said Joyce DeFranco. She said her husband's influence on music will last long beyond his lifetime.
DeFranco began his career as a teenager in Philadelphia and went on to play with legendary bands including ones led by Tommy Dorsey, Count Basie, Gene Krupa and Charlie Barnett.
Composer Nelson Riddle wrote the musical 'Cross Country Suite' in 1958 for DeFranco, and Nat King Cole introduced DeFranco when he premiered the work at the Hollywood Bowl.
DeFranco is survived by his wife and his son, Chad DeFranco.