The 47-year-old actress was the guest of honour at the Amalfi Coast event and she spoke to the attendees of the children's festival to talk about her career in Hollywood.
When Aniston was asked to suggest a solution for more female-centred stories to be told in Hollywood, the star encouraged the aspiring writers and filmmakers in the audience to step away from the obsession with social media and create projects grounded in the real world, reported E! online.
The actress was also moved to tears by one teen, who asked the A-lister if she ever woke up in the morning and didn't recognise who she really was.
"There are not enough fingers and toes in this entire room to count how many times that moment has happened to me," Aniston confessed as she wiped tears from her eyes.
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"My heart can't take it or the pain is too great, or am I good enough? Will I survive? And you just have to sort of somehow miraculously overcome. You just go, 'I can't, yes I can, yes you can.'
"And also know that your actors, your idols, your icons, whatever you call them, have all had that experience in their lives many, many times.
Aniston's speech at Giffoni echoed similar sentiments in an emotional letter she penned earlier this month hitting out at the constant media furore surrounding her private life.