The 46-year-old actress will also produce along with Steve Barnett, Bernie Goldmann and Kristin Hahn, said The Hollywood Reporter.
Aniston will play sports manager Denise White in the movie, for which Fox has bought the pitch from "Dallas Buyers Club" screenwriter Melisa Wallack.
The story revolves around White, a former Miss USA contestant who went on to found a sports firm for high-end athletes.