The 42-year-old banked a fortune from her 18 perfumes released in the last 10 years, easily outselling her nearest rivals Sarah Jessica Parker and Madonna, reported Contactmusic.
Britney Spears' range, which includes Believe and Fantasy, is the fourth biggest seller, and Canadian rocker Avril Lavigne rounds out the top five in the list compiled by online beauty products retailer Escentual.Com.
"J-Lo remains the queen of the scent industry. I am sure starring on 'American Idol' with Simon Cowell has helped sales. The celebrity perfume market is massive and fashion can change very quickly, sometimes literally overnight," said the company's founder Rakesh Aggarwal.