The 41-year-old hit out at the family - who have their own reality TV show, 'Keeping Up with the Kardashians' - for being in the limelight just to be famous rather than be appreciated for their skills, reported Contactmusic.
"Oh, all those ridiculous people with zero talent who spend their lives making sure everyone knows their name. Those stupid, stupid people," he said.
The actor, who struggled for years to make it as an actor and at times found himself homeless, said that despite becoming a successful actor, he never wanted to be famous and was shocked when his idols began to recognise him.
"One minute I'm homeless. The next I'm still homeless, but I'm in a tuxedo, on my way to the Oscars, stopping at a coffee shop to brush my teeth because I don't have running water.
"The next minute Jack Nicholson, someone I've admired my entire life, is right in front of me saying my name. Then he's saying the names of two movies I did and I'm like, 'Jesus, all I wanted to do was be in a movie that would play in a big enough theatre that my family would get to see it. And now this.' What can I say? It's weird," he said.