The 37-year-old actress will be recognised by the annual French festival - which pays tribute to American cinema - for her career, reported Variety.
Festival director, Bruno Barde said, "The tribute is a token of our affection, admiration, recognition and esteem for the talent of the recipient. For the past few years, we have been paying tribute to those actresses who embody the cinema of today and who will form the legacy of tomorrow.
"When we first discovered Jessica Chastain, we had the definite feeling that here was someone special on-screen. Through her successive roles, she has confirmed her emotional capacity to grab the limelight.
Chastain can be next seen in 'Interstellar', 'The Disappearance of Eleanor Rigby', 'Miss Julie' and 'A Violent Year'.
She will also appear in Guillermo del Toro's 'Crimson Peak', out in 2015, with Tom Hiddleston, Mia Wasikowska and Charlie Hunnam.
The Deauville American Film Festival will take place this year on September 5-14.