The two-time Oscar-winning actress has given herself "a couple of years" in the showbiz before bowing out, reported Us magazine.
"I want a new adventure in life, I've been doing this for quite a long time," Lange said while talking about her four-decade-old career on Today show.
The 64-year-old actress said the obvious next step for her after quiting acting would be to remain "open to the possibility".
"I think you can only do that if you're not committed to something else," she said.