Jerusalem's Latin patriarch will lead a procession to Bethlehem and celebrate midnight mass in the holy city attended by Palestinian president Mahmud Abbas and other dignitaries.
Christmas this year comes as conflicts and natural disasters have stricken Christians worldwide, from the historic Syrian town of Maalula where residents still speak Jesus's ancient Aramaic, to typhoon-hit Tacloban in the Philippines.
Filipinos who survived the deadly typhoon Haiyan defiantly prepared to celebrate Christmas in their ruined communities today where hogs were being roasted, festive trees adorned streets and churches were filled to overflowing.
In a Christmas message last week, Fuad Twal, the Latin patriarch of Jerusalem, spoke of the sufferings of the Palestinian people and the vicious conflict that has rocked Syria for 33 months.
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Twal, the top Catholic cleric in the Holy Land, said Israeli-Palestinian peace talks that resumed in July after a three-year hiatus were being hampered by Israeli settlement construction.
"As long as this problem is not resolved, the people of our region will suffer," said Twal, adding the Israel-Palestinian conflict was "a major obstacle" to Middle East stability.
"As the Syrian problem cannot be resolved by the force of arms," he said.
"We call on all political leaders to assume the responsibility for finding a mutually acceptable political solution that will end the senseless violence and uphold respect for the dignity of people."
For Maalula residents it will be a grim Christmas as hundreds of Christians have fled a rebel assault on their ancient hamlet and have taken shelter in the Syrian capital Damascus.