Chasing 317 for a win at the Perintalmanna Cricket Stadium, the Sanju Samson-led Kerala were bundled out for 183 after the host batsmen failed to counter Nadeem's (7-64) spin.
Captain and pace spearhead Varun Aaron, who wnet wicketless in the second innings, had contributed with a five-wicket haul in the first.
Jharkhand opener Ishan Kishan, who top-scored with a valuable 58 in the second innings and the visiting team's middle-order also contributed to the win.
Jharkhand 202 and 262
Kerala 148 and 183 all out in 63.5 overs (Akshay Kodoth 72; Shahbaz Nadeem 7-64).
Points: Jharkhand 6, Kerala 0.