"Through their shameful, heinous, inhumane and cruel words and acts, (these groups) have offended the religion... The holy book and the Muslim people more than any other enemy," said Nasrallah.
And he said that offence was "greater than the books, the films and the cartoons that have insulted the prophet."
Nasrallah alluded to a video entitled "The Innocence of Muslims," which was distributed online in 2012 and caused an uproar among Muslim communities all over the world.