"It is not an ordinary incident. Despite warnings and and continuing tension, why was it not prevented. Someone has to take the responsiblity," he told reporters here.
Asked whether Akhilesh should own up responsibility and resign, the minister of state for HRD said "absolutely".
"He should resign," Prasada said describing the Muzaffarnagar incident as most unfortunate.
It was for the first time in 21 years that Army had to be called out in the state after 1990, he said.
More From This Section
On senior Samajwadi Party leader Azam Khan keeping away from Cabinet and party meetings, the minister refused to comment.
When asked who could benefit from the Muzaffarnagar incident, Prasada said it was obvious that the BJP and the SP would gain from it.
Asked to elaborate, he said "in politics the benefit is not seen directly."
On September 10, Prasada suggested that Akhilesh should quit in the wake of Muzaffarnagar clashes.
He had also slammed the Samajwadi Party alleging it was hand-in-glove with the BJP and was trying to criminalise things in the run up to elections.