Mufti's visit to the centre at R S Pura coincided with 'Diwali', the festival of lights.
She extended greetings to the children and wished them happy and prosperous times ahead, he said.
Interacting with the inmates, the chief minister said though the Government was working for the welfare of orphans and the destitute, but it was the obligation of all citizens to play a role towards proper rehabilitation and social integration of these victims of fate.
During the visit, the chief minister sat with the inmates of the children's home and interacted with them, an official spokesman said. The children shared their interests like poetry, singing and painting with the chief minister.
The spokesman said that a large number of people from different walks of life also met Mufti.