The 39-year-old star, who appeared briefly in a cameo at the end of the 2015 comedy, will play a more prominent role in the second movie, according to The Hollywood Reporter.
He joins returning stars Will Ferrell and Mark Wahlberg in the Sean Anders follow-up.
The movie is about to begin production in Boston.
Cena's upcoming films include Amazon's thriller "The Wall" and Universal's comedy "The Pact".
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