Promoting his latest film, 'Maps to The Stars', Cusack did not hold back, criticising ageism in Hollywood, as well as misogyny and what he sees as an increasingly broken studio system, said the Hollywood Reporter.
"LA seems to be a place where a guy can say he's a 'life-coach-channeller-masseur'. It just seems to be ripe with all these frontier crazies.
"People are looking to turn their pain into beautiful art, but they also want to be famous. And there's so much money - so of course all the predators come in," he said.
"I got another 15, 20 years before they say I'm old. For women it's brutal. Bruce's thing about if you're 26, you're menopausal? It's only absurd because it's a little bit further than the truth.
"I have actress friends who are being put out to pasture at 29. They just want to open up another can of hot 22. It's becoming almost like kiddie porn," he added.