The 39-year-old singer said he loves the emotional drama.
"Just saw the first episode of 'This is Us' and I'm hooked. Cryin'and hooked. Not even wiping away tears for the next episodes. Just gonna let the first ones create tracks for a more even, efficient flow," he wrote on Twitter.
Moore was thrilled to find out about the show's famous fan and wrote back saying: "Glad you're digging it."
And Mayer replied: "Beyond dig, @TheMandyMoore. I'm about to attempt one of the most emotionally reckless stunts ever: watching an episode ON AN AIRPLANE (sic).