The 51-year-old actor was pulled over following numerous calls to the police complaining about an erratic driver in the area, reported Variety.
Stamos was transported to a nearby hospital as police thought he needed medical attention due to a possible medical condition.
He was cited for driving under the influence and released to the care of the hospital.
The "Bye Bye Birdie" star will be seen on Fox's upcoming fall family sitcom "Grandfathered," and is set to appear on Netflix's "Fuller House" sequel.