Located about 25 kilometres from the French Riviera resort of Saint Tropez, the property is in the village of Plan de la Tour and has 1,000 square metres of living space spread across the 15-hectare (37-acre) property.
"Johnny has decided to sell the Plan de la Tour property to close this chapter of his life and move on," Alexander Kraft, head of Sotheby's International Realty France, wrote in a description of the estate.
"He decorated everything, paying attention to the smallest detail, in a 'Bohemian' or 'artistic' style and the property is being sold with all its contents, books, DVDs, furniture and some works of art," Kraft told AFP.
"This type of thing is very rare for a property that belongs to a star of his calibre."
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Depp, 52, carried out extensive renovations on the house.
"Over several years, he painstakingly restored and decorated all the houses of the village one by one, bringing his very personal touch to the project and creating a property of exceptional character," said Kraft's description of the property.
Depp lived there during his 14-year relationship with French singer and actress Vanessa Paradis, which ended in 2012.
He married American actress Amber Heard earlier this year.