Depp, 53, was previously with the United Talent Agency.
His move comes after a series of failed movies and a very public split from Amber Heard. The pair reached a divorce settlement of USD 7 million after Amber accused Johnny of domestic assault, reported Deadline.
"We had a great 30-year run with Johnny and we wish him well," said a UTA spokesman said.
Depp's diverse performances have earned him more than USD 7 billion at the worldwide box office, including films like "Edward Scissorhands," "Blow," "Pirates of the Caribbean," "Alice Through the Looking Glass" and "Black Mass."
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With his career spanning more than three decades, Depp has been nominated for several Oscars and won a Golden Globe for his 2008 performance in "Sweeney Todd: The Demon Barber of Fleet Street."
Depp will next star in Universal's "The Invisible Man," an on-screen adaptation of HG Wells' 1933 novel.
He is also set to star in "Murder on the Orient Express" and "Labyrinth," which will explore the murders of Tupac Shakur and Notorious B.I.G.
Depp is managed by Christi Dembrowski and represented by attorney Jacob A Bloom at Bloom Hergott Diemer Rosenthal LaViolette Feldman Schenkman & Goodman.
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