The Welsh actor will join Anthony Hopkins, who will be portraying Pope Francis' predecessor, Pope Benedict, Deadline reported.
Pryce is no stranger to playing a role of a religion leader. On HBO's "Game of Thrones", the actor played High Sparrow, a leader of a fictional faith movement.
As for Hopkins, he stars on "Westworld" as Dr Robert Ford, a character which earns him an Emmy nomination for Outstanding Lead Actor in Drama Series.
Screenwriter Anthony McCarten ("The Theory of Everything") is set to adapt his own stage play into a script for the movie.
The filming of "The Pope" is expected to begin this November in Argentina.
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