"I just feel like I'm on a first date always," he said in an interview with LinkedIn, as reported by Page Six.
"I don't feel like any success I've had means the next one will be successful, it keeps me on my toes and I have a lot of energy to succeed because I don't get cocky or lazy. Again, in comedy I just don't know."
Apatow, 49, is known for his hit films including "Knocked Up", "Superbad", "Pineapple Express", "Bridesmaids", and "Trainwreck."