The 51-year-old beauty has signed up to play the abusive Christian tryant who terrorises her teenage daughter in the Stephen King tale, reported Sun online.
"Kick-Ass" star Chloe Moretz will play the girl, who develops psychic powers after being bullied at home and at school.
The role was played by Sissy Spacek in the 1976 original, with Piper Laurie as her fanatical mother.
Moretz, who beat off competition from Dakota Fanning and Saoirse Ronan for the iconic role, recently said the new movie would be darker and more psychological.
"It's darker and much more psychological. More 'Black Swan'. You're really looking into her mind and it really looks into the relationship of Margaret and Carrie. It's set in modern time, so it's a lot different," Moretz said.
The remake is scheduled to release on March 15, 2013.