The popular 90s sitcom gave Aniston her breakthrough role of Rachel Green.
The 46-year-old actor admitted he is glad he missed the try-outs because he wouldn't have been prepared for the fame achieved by the stars of the show.
Recalling the audition opportunity in a new interview with Mr Porter's The Journal, Theroux said, "No, I didn't bother. I slept in that day. I wouldn't have been prepared for the fame."
Besides Aniston, "Friends" also starred Courteney Cox, Lisa Kudrow, Matt LeBlanc, Matthew Perry and David Schwimmer.