The couple have been together for five years, and have enjoyed a ten month engagement, reported People magazine.
"It's great to be married, the ceremony was beautiful and it was so special to be surrounded by our family and friends," the couple said in a statement.
They enjoyed three days of celebrations, which began on Wednesday at a beach party that included fireworks and live music. On Thursday they hosted another party which included anti-pasti and open fires.
Both Biel and Timberlake had been honest about their wedding and relationship to the world.
"I think it's important to remember that you go into something like marriage knowing that you don't know very much about it at all," Timberlake had said.
The wedding was awash with security, and reportedly guests were required to sign a non-disclosure agreement to protect the privacy of the newlyweds.
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The guest list included Jimmy Fallon, Timbaland, Andy Samberg and Beverly Mitchell.
Both Timberlake and Biel have a long history of Hollywood dating, with Timberlake famously dating Britney Spears for many years, as well as a highly publicised relationship with Cameron Diaz.
Biel has dated Ryan Reynolds in the past.