The 36-year-old singer will headline at the Circuit of The Americas in Austin on October 21, reported Billboard.
The ten-time Grammy winner will be on the stage for the post-race concert during the three-day affair.
"We're thrilled to have Justin Timberlake perform at this year's United States Grand Prix... The combination of the incredible entertainment off and on-track with the amazing backdrop of Austin - and everything it has to offer - provides fans with an exhilarating weekend that simply cannot be missed," says Bobby Epstein, chairman of Circuit of The Americas.