The couple, who married in Italy last month, are currently based in Los Angeles, but want to relocate to the "Social Network" star's hometown of Memphis when they are ready to have kids, reported Ok magazine.
"He hates the idea of raising his kids in Los Angeles with all of the paparazzi and constant attention. Plus, Justin thinks the South is the best place in the world to grow up, he wants that for his kids. Beneath all of the Hollywood nonsense, Justin's a simple country guy who always wanted a big family," a source said.
Although the plan was Timberlake's idea, Biel, 30, is more than happy to follow his lead.
"Jessica agreed to that plan 100 per cent. She's totally up for a change of scene. She wants a slower pace of life now she's older. She is super domestic, her favourite hobby is baking but she even knits and does needlepoint," the source added.