Reddy, who founded DRL in 1984, was ailing for some time, a company statement said. He was 72.
He died of liver cancer at 1545 hrs at the Apollo Hospital in Hyderabad.
Many in the industry saw in him a drug discovery pioneer. Dr Reddy set up his R&D facility at what was once his farm.
A chemical engineer who also served as a member on Prime Minister's Council on Trade & Industry, Reddy is survived by wife Samrajyam, daughter Anuradha and son K Satish Reddy, who is the managing director and COO of the company. His son-in-law G V Prasad is the Vice Chairman and CEO of the company.
Reddy spearheaded and founded the Neo-natal Intensive Care and Emergencies called 'NICE Foundation', the only institute for new-borns in Asia.
In 1998, Reddy set up Naandi Foundation for proving safe drinking water in rural areas. The foundation gives midday meals to 1.3 million government school-going children and farmers, a DRL statement said.