This is the second rail accident in the state in four days.
The train travelling from Azamgarh to Delhi collided with a dumper at around 2:50 am between Pata and Achhalda railway stations, a spokesperson for the North Central Railway (NCR) said.
One bogie of the train overturned due to impact of the collision and some compartments jumped the rails between Acchalda and Pata railway stations after crossing Kanpur, Superintendent of Police, Auraiya, Sanjeev Tyagi said.
A dumper broke the railway fence and hit the engine of Kaifiyat Express causing derailment, the Railway Ministry said in a statement.
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"There are no casualties but 25 persons have been injured," the statement said.
Earlier, M C Chauhan, General Manager of NCR has said that at least 50 people were injured in the accident.
Railway Minister Suresh Prabhu tweeted, "A dumper hit the locomotive of the Kaifiyat Express, resulting in derailment. Some passengers have received injuries and have been shifted to nearby hospitals".
Kaifiyat Express travels between Azamgarh in Uttar Pradesh and Delhi and the collision has impacted the train operations on the Delhi-Howrah route.
Five trains including Howrah-New Delhi Rajdhani have been diverted and seven trains including Kanpur-New Delhi Shatabdi express have been cancelled. Since both UP and DOWN lines are blocked, around 40 local trains were also being diverted.
On receiving information about the mishap, senior officials rushed to the accident site which comes under Acchalda police station, around 180 km from Lucknow.
This is the second rail accident since last Saturday. Utkal Express had derailed in Muzaffarnagar district of UP, killing 22 people and injuring 156.
A spokesman for NCR said rescue operations have been concluded and all injured were sent to hospitals nearby.
General Manager, NCR, M C Chauhan and the Divisional Regional Manager have rushed to the spot.