The Kolkata outfit maintained its winning streak and dominated the proceedings right from the start against the Goan side.
Kalighat players displayed impressive show scoring all the four goals before the breather while Vasco striker Lezly Fernandez reduced the margin in the 69th minute.
Forward James Gbilee put Kalighat in the lead as early as in the 3rd minute while Chizoba struck twice in the 28th and 41st minute respectively. Skipper Tanmoy Kundu scored in the 45th minute.
With two wins in as many matches, Kalighat topped the chart with six points. In their earlier match on Wednesday, Kalighat trounced Royal Wahindoh FC 6-0.