"I have an experience with this kind of approach and what I have seen is when you say criminal, that's a very broad term. It's not a monolith. There's a whole range of behaviors that can qualify as being called a crime," Harris told Miami Herald in an interview.
Harris, 52, is of both India and African heritage and is in Washington DC for a week-long orientation programme for new Senators. She is the first Senator of Indian heritage.
"A DUI (driving under the influence of drugs or alcohol) is very different from rape. And as a career prosecutor I have constantly and consistently seen that one of the best tools in the tool belt of a predator of an undocumented immigrant, be it rape, be it domestic violence, be it fraud, one of the best tools that the predator has is to look at the victim and tell the victim, 'if you report this, it is you who will be treated like a criminal'," she said.
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Harris, who was endorsed by outgoing President Barack Obama in her Senate race, is a fierce opponent of Trump.
"I am suspicious of that approach... And here's the other reality of it, every federal agency, every state or local agency, especially in law enforcement, will tell you they have limited resources and as far as I'm concerned I prefer that those resources as it relates in particular to nonviolent, nonserious crime, go into helping me - I'm still AG - do the work we need to do in dealing with transnational criminal organizations, who have a proven track record of trafficking in guns and drugs and humans," Harris said.
Harris has already talked with her future Democratic colleagues about "banding together" to protect immigrants from what she described as Trump's draconian immigration proposals.
However, Harris said she would co-operate with the president-elect on infrastructure issue.