The outage was caused when Guddu-Dadu transmission line tripped due to a technical fault.
"The breakdown was caused by a technical fault in one of the high voltage transmission lines supplying electricity to Karachi from the national grid," said Ahmad Faraz, Spokesman of Karachi Electricity Supply Corporation of K-Electric.
"Power failure happened around 3.45 am when 500 KV power line got tripped due to moisture," he said.
Karachi, a city of over 23 million people, and Hyderabad and Jamshoro districts plunged into darkness due to power failure.
Pakistan's power line system is old and needs repair as well replacement.
Recently, large swaths of Punjab and Khyber-Pakhtunkhwa provinces faced major power breakdown after the national grid system collapsed due to low frequency ratio.